Micky van de Ven Brace Ends The Toffees' Run at New Stadium
Micky van de Ven became the initial defender to net two goals in a English top-flight game for Tottenham since the Belgian defender in March 2013.
At a glance
Micky Van de Ven heads home two times in first half
The home side's Jake O'Brien has goal ruled after VAR review
Pape Matar Sarr scores final goal in dying moments
This loss is the Merseyside club's initial at their new ground
The Tottenham defender found the net twice as Spurs extended their winning streak in away games in the Premier League and delivered Everton their initial loss at their new home.
The Toffees were undefeated in their five previous fixtures at their new ground at Bramley-Moore Dock, having departed their historic home behind after 133 years at the end of last season.
But Tottenham's leader Van de Ven pounced on two occasions from set-pieces in the first half to put their strong form at jeopardy, and they were failed to turn it around before the midfielder - set up by ex-Everton forward the Brazilian - nodded in a final goal to seal the victory.
The Everton defender believed he had equalized the tally a short while after the defender's first goal, glancing a powerful header past the Spurs keeper from an set-piece.
Beto, in the meantime, missed a number of chances, while the Italian goalkeeper made a succession of fine saves to ensure the London club went five matches on the road unbeaten in the English top flight.
But the video assistant referee intervened, instructing Craig Pawson to review the goal on the screen and the referee decided that Jack Grealish and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
The win elevates Thomas Frank's side up to third in the division, five points off local foes and table-toppers the Gunners.
Everton remain in 14th position and are six points ahead of the drop zone.
Spurs breakdown: Van de Ven fulfils role at both ends of pitch
After a uninspiring weekday display in the Champions League against the French side, where they managed a only two shots on target, Frank chose the French striker in attack instead of former Toffees player Richarlison.
The summer signing was failed to make much of an impact before being replaced for the substitute after 60 minutes on the field, but it emerged he proved unnecessary in the final outcome.
Centre-back the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's first goal came from a cleverly executed corner routine, with Rodrigo Bentancur heading the ball toward the six-yard box for an unmarked the defender to head home.
And the captain - filling in as skipper in the Argentine's unavailability - notched his next goal in added time as he rose above the England keeper to head home.
Van de Ven was just as outstanding in defence, combining well with his defensive colleague as the pair dealt superbly with the 34 crosses thrown their way by Everton.
Everton analysis: Toffees missing finishing touch
Everton's recent stadium had been a happy hunting ground, but it seems the novelty may have worn off somewhat and fans headed to the gates after the midfielder's third for Spurs.
The end in Everton's winning streak at home will not be a major concern for the manager, but their striker situation will be.
Beto and Thierno Barry - the Everton's pair of recognised strikers - had scored just one league goal combined before the weekend's match.
And they were unable to contribute to that poor tally on a wet and gloomy evening on in Liverpool.
The striker's form was summed up when he opted to overhead kick a clear chance from close range, despite having room and opportunity to readjust for a simpler attempt that would have challenged Vicario.
Barry, as well, was unable to make an impact after replacing the starter in the 65th minute.
It was not for a lack of chance. The majority of Everton's attacks came through the winger and Ndiaye, who relentlessly delivered dangerous balls into the Tottenham penalty area.
What next for these two sides?
The Toffees: The team travel to the Stadium of Light in the top flight on Monday, 3 November at 8 PM.
Tottenham: Spurs go to Newcastle's ground on Wednesday, 29 October for their fourth-round Carabao Cup match against the Magpies.